Human Sera
Cayman Chemical AtIpamezole 100mg
An α2A-AR antagonist (Ki = 1.86 nM); selective for α2A-ARs over α2B- and α1-ARs (Kis = 1,949.83 and 13,300 nM, respectively), as well as over 40 receptors, ion channels, and transporters (IC50s = 540->10,000 nM); reverses medetomidine-induced bradycardia and sedation in dogs at 0.04, 0.08, and 1.2 mg/kg; enhances apomorphine- or L-DOPA-induced contralateral circling behavior and prolongs the duration of action of L-DOPA in a rat model of Parkinson’s disease at 0.3 mg/kg
Cayman Chemical mthyl DIethyldIthIocrbmt 50mg
An active metabolite of disulfiram; inhibits liver low Km ALDH in rats (ID50 = 15.5 mg/kg); decreases MAP and increases heart rate during ethanol challenge in rats at 20.6 mg/kg
Perkin Elmer US LLC Portability Pack for the Spectrum Two
The PerkinElmer Spectrum Two is a robust and transportable FT-IR system platform enabling simple, reliable FT-IR solutions for product quality testing. A range of plug-and-play sampling accessories and application packages ensure the best solution for a range of applications. Whatever your specific IR analysis requirements, the Spectrum Two delivers outstanding performance and reliability to provide high-performance, dependable IR measurement solutions.
Cayman Chemical Clevdpn 50mg
An inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes); preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively); decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats (ED30s = 316 and 58 nmol/kg, respectively)
Cayman Chemical CarteololhydrochlorIde 100mg
A β-adrenergic receptor antagonist (Kd = 13 nM); blocks isoproterenol-induced increases in heart rate, contractile force, and blood pressure in vagotomized dogs (ED50s = 2.3, 3.1, and 1.8 UG/kg, respectively); the (R) and (S)-enantiomers EAch reduce intraocular pressure in rabbits (1% solution)
Cayman Chemical nlfInavIrmesylate 50mg
An orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM) that is used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection
Cayman Chemical BrasInazole 50mg
An inhibitor of brassinosteroid biosynthesis that at 1 µM can induce morphological changes, including dwarfism and altered leaf color and curling, in dark-grown Arabidopsis and light-grown cress
Cayman Chemical Cholesterol a-LInolenate 50mg
A cholesterol ester; found in fatty streaks and atherosclerotic plaques isolated from human aorta
Cayman Chemical DIhydroergotamInmesylate 50mg
An agonist of 5-HT1B and 5-HT1D receptors (Kis = 0.3 and 2.5 nM, respectively, for human receptors); binds to dopamine D2 and D3 as well as 5-HT2A receptors (K0.5s = 5, 16, and 38 nM, respectively) but has lower affinity for D1, 5-HT2C, and 5-HT3 receptors (K0.5s = 2,779, 298, and >10,000 nM, respectively); binds to α-adrenergic receptors; increases the mechanical pain threshold in a rat model of neuropathic pain when used at doses of 50 and 100 mg/kg
Cayman Chemical PelargonIdInchlorIde 50mg
An anthocyanidin with diverse biological activities; scavenges superoxide anions in cell-free assays (IC50 = 130 UG/ml); inhibits hydrogen peroxide-induced lipid peroxidation in rat brain homogenates (IC50 = 85 µM); reduces serum levels of ALT and AST, hepatocyte apoptosis, and hepatic levels of IL-1β, IL-6, TNF-α, and TGF-β in a mouse model of acetaminophen-induced hepatotoxicity at 3 mg/kg; increases survival and reduces pulmonary fibrosis and leukocyte infiltration in a mouse model of LPS-induced endotoxemia; reduces serum levels of NO, TNF-α, and IL-6 and increases renal MPO, SOD, and CAT activities, as well as increases survival, in a mouse model of cecal ligation and puncture-induced sepsis from 0.04-0.4 mg/kg; decreases escape latency in the Morris water maze, reduces hippocampal MDA levels, and increases hippocampal AChE activity in a rat model of Aβ (25-35)-induced Alzheimer's disease
Cayman Chemical BarnIdIpInhydrochlorIde 100mg
A calcium channel blocker that selectively antagonizes cardiovascular calcium channels; demonstrates antihypertensive activity by reducing peripheral vascular resistance; decreases blood pressure in spontaneously hypertensive rats
Cayman Chemical 2 5-nhydro-D-mnItol 50mg
An antimetabolic fructose analogue that increases food intake in rats
Cayman Chemical ButabIndIdeoxalate 50mg
A potent inhibitor of CCK-inactivating peptidase/TPP-2 (Ki = 7 nM); selective for CCK-inactivating peptidase/TPP-2 over a panel of serine proteases (Kis = >1 μM) as well as CCK receptors (Kis = >0.1 mM); increases levels of CCK octapeptide in depolarized rat cerebral cortex slices; inhibits CCK-inactivating peptidase/TPP-2 in mouse liver and brain (ID50s = 1.1 and 6.8 mg/kg, respectively); enhances CCK octapeptide-induced delay in gastric emptying and reduces food intake in mice
Cayman Chemical SotalolhydrochlorIde 100mg
A β-AR antagonist (IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent; decreases IK in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles at 100 μM; decreases heart rate and increases blood pressure and the cardiac FRP in a canine model of PES-induced ventricular tachycardia